Rational development of multicomponent mRNA vaccine candidates against mpoxArticle Published on 2023-12-012023-06-10 Journal: Emerging Microbes & Infections [Category] Fulltext, 원숭이두창, [키워드] mouse model Mpox virus mRNA vaccine multicomponent protective antigen. [DOI] 10.1080/22221751.2023.2192815 PMC 바로가기
Pharmacokinetic and Pharmacodynamic Effects of Polyclonal Antibodies against SARS-CoV2 in MiceArticle Published on 2022-12-302023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] COVID-19 mouse model Pharmacodynamics pharmacokinetics. [DOI] 10.3390/v15010123 PMC 바로가기
Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 GeneArticle Published on 2022-12-282023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] adeno-associated virus Angiotensin-converting enzyme 2 (ACE2) animal model COVID-19 host specificity Infection mouse model pandemic SARS-CoV-2 species specificity Virology. [DOI] 10.3390/v15010085 PMC 바로가기
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusionArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies antibody approved B cell BCR binding epitope blocked CDR3 contribute described elicited Health humanized immunogen inhibiting Last Lattice mechanism of action membrane fusion mice Modification mouse model neutralization activity neutralize neutralized Neutralizing antibodies neutralizing antibody omicron Pathogens RBD receptor receptor-binding motif Recombination SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant sequence Spike protein therapeutic therapeutic potential Vaccine Wuhan-Hu-1 [DOI] 10.1126/sciimmunol.add5446 PMC 바로가기
Efficacy of COVID-HIGIV in animal models of SARS-CoV-2 infectionArticle Published on 2022-10-102022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acute respiratory syndrome animal model anti-SARS-CoV-2 baseline Body weight loss caused China controls convalescent plasma coronavirus COVID-19 COVID-19 vaccines deaths Efficacy evaluated faster hamster hamsters Hospitalization Human Immunoglobulin intravenous Lung inflammation Lung pathology Lungs mice monoclonal antibody mouse model ongoing trial PBS plasma reduced SARS-CoV-2 SARS-COV-2 infection significantly Spread Support therapeutic option treated Treatment Viral load virus was reduced worldwide pandemic [DOI] 10.1038/s41598-022-21223-2 PMC 바로가기
Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expressionArticle Published on 2022-09-262022-11-16 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] ACE2 analysis approach bioinformatics Concordance COVID-19 debatable differentially expressed gene expressed expression Gene Expression hACE2 Human immune signature Immunity immunopathology inflammatory pathway K18-hACE2 lung damage Lungs mice mouse model orthologue overlap promoter SARS-CoV-2 single copy transcriptional profile transcriptional response Treatment Viral load virus wild-type [DOI] 10.1371/journal.ppat.1010867 PMC 바로가기
Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadthArticle Published on 2022-09-222022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] activity antibodies antibody antibody cocktail antibody resistance binding breadth computational simulation costly COVID-19 crosslinking cryo-EM Engineering epitope exhibit IMPROVE Infection mouse model Neutralizing Neutralizing activity parental RBD reduce SARS-CoV-2 SARS-CoV-2 variant the receptor-binding domain therapeutic efficacy therapy variants virus-neutralizing X-ray crystallography [DOI] 10.1038/s41467-022-33284-y PMC 바로가기
Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cellsArticle Published on 2022-09-212022-11-15 Journal: eLife [Category] 바이오마커, 유전자 메커니즘, [키워드] alveolar alveolar epithelial cell alveolar epithelium alveolar regeneration Basal cell basal cells Biomarkers cause Cell Cell Biology Complete COVID-19 ectopic epithelial epithelial cell function IMPROVE increase independent Infection lineages lung lung parenchyma lung regeneration Lungs mechanism mice mouse mouse model Notch other organs proliferate promote promoted regenerative regenerative medicine regulate significantly stem cells suggested suppressed Tamoxifen tuft cell tuft cells viral infection Viral infection. Wnt [DOI] 10.7554/eLife.78217 PMC 바로가기
A Multitrait Locus Regulates Sarbecovirus PathogenesisArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome analysis approach CCR9 chromosome 9 collaborative cross conserved coronavirus coronavirus disease Coronavirus infection cross CXCR6 disease facilitate Follow-up Genes Genetic genetic determinant genetic mapping Genetic variation GWAS help highly pathogenic Host host response host susceptibility humans identify implementation Infection Infectious disease influence loci locus mice Mortality mouse model outcome outcomes Pathogenesis pathogenic Precision predict Protective regulate sarbecovirus Sarbecoviruses sarbecoviruses. SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 infections severe disease severity strain susceptibility susceptibility allele variety Viral diseases Virus Disease [DOI] 10.1128/mbio.01454-22 PMC 바로가기
A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 InfectionSARS-CoV-2 감염에 대한 항바이러스제의 효능을 평가하기 위한 SCID 마우스 모델Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 치료제, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral drug antiviral drugs antiviral efficacy antivirals B.1.351 B.1.351 variant BALB/c Beta Beta variant binding C57BL/6 CAGE coronavirus Culture drug hamsters Infection infectious virus titer infectious virus titers Infective dose inhibitors intrinsic lack log lung Lung pathology Lungs male mice Model moderate molnupiravir mouse mouse model Mouse models Nirmatrelvir nirmatrelvir. offer Postinfection reagent receptor reduced replicate Replication reported SARS-CoV-2 SARS-CoV-2 mouse model SARS-CoV-2 strain SARS-CoV2 SCID significantly TCID These data tissue tissue culture twice a day Validity variant variants variants of concern Viral load virus virus strain wild-type [DOI] 10.1128/jvi.00758-22 PMC 바로가기 [Article Type] Article